Yes, always.
The truth is that you cannot physically target a single muscle when you lift, and when you try you end up using lacklustre isolation exercises that are usually only difficult because of poor leverage rather than actual muscular effort.
Even with a curl, you are utilising the forearms to grip the bar, the bicep as a prime mover, the brachialis as a synergist, the tricep as an antagonist, and the shoulder girdle to stabilize the arm.
Not to mention the core to stabilize the trunk.
Training with large compound movements will elicit a greater hormonal response, and thus larger cause for the body to adapt and grow simple because they utilize large amounts of muscle across multiple joints.
Why accomplish an inferior amount of work with 4 isolation movments, when you can achieve even more with a single compound?
I.e. - Hyperextensions, shrugs, reverse flys, leg curls and calve raises....or deadlifts.
Thats just a real no brainer